N1 Lab Solutions
RiboCraft Alpha

Revolutionizing Your RNA Research Toolbox

Who we are

N1 Lab leverages the core technology background of Stanford University, built upon over 30 years of research and validation experience from the laboratories of members of the National Academy of Sciences. Dedicated to innovation and breakthroughs in RNA delivery technology, N1 Lab follows the rigorous pathways, strategies, and quality standards of drug development. Focusing on developing cutting-edge biomolecular delivery systems and efficient molecular formulations, N1 Lab applies these advanced technologies to RNA drug delivery, achieving highly efficient transfection and stability both inside and outside cells. This enables groundbreaking solutions in gene delivery, gene therapy, and organ targeting.

RiboCraft Alpha

>> Simple formulation protocol

>> Fast, controlled, and efficient expression

>> Buffer compatibility

>> Enhanced long-term stability

>> Stable particle size

>> Safe in vitro & in vivo

Product Features

Enhanced Efficiency

Our reagent significantly improves transfection efficiency, saving researchers time and resources

Stability and Consistency

With high stability, our reagent consistently delivers reliable results, ensuring reproducibility in experiments

Low Toxicity

User-Friendly

Our reagent has minimal cytotoxicity, reducing the risk of cell damage and influencing accurate data interpretation

Designed with ease of use in mind, our reagent simplifies the transfection process, enabling researchers to focus on their experiments

What is RiboCraft?

Ribo (Ribonucleic Acid)

RNA, a fundamental molecule in biology that plays a crucial role in the coding, decoding, regulation, and expression of genes.

Craft

An activity involving technique and expertise in making things perfect. When used in a technological or scientific context, it imply the skillful creation or engineering of something.

Introduction

RiboCraft Alpha, an RNA delivery tool that independently developed by N1 Life, Inc., demonstrates outstanding RNA gene expression and transfection efficiency across a wide range of cell lines. RiboCraft Alpha possesses stable physicochemical properties, is colorless, odorless, water-soluble, and highly safe. Its simple usage can be easily implemented under standard laboratory conditions, and once prepared, it remains stable at room temperature for up to 30 minutes, ensuring the reproducibility and consistency of results.

Experimental data show that RiboCraft Alpha not only maintains compatibility with different types of physiological buffers but also exhibits stable transfection efficiency under pH conditions ranging from 4 to 8. It demonstrates serum tolerance during mRNA transfection and exhibits excellent stability across various temperatures. This key feature enhances its practicality in complex biological environments. Additionally, by adjusting the ratio of RiboCraft Alpha to mRNA, it can achieve high transfection efficiency across a wide range of mRNA doses, expanding its applicability in various delivery scenarios.

Not only does RiboCraft Alpha outperform industry-standard reagents in mRNA transfection, but it also shows superior results in siRNA tests. Its powerful performance extends to gene editing, successfully delivering Cas9 mRNA and sgRNA, achieving up to 95% editing efficiency in vitro. RiboCraft Alpha is positioned as a versatile and powerful tool, poised to accelerate research and development in the fields of RNA therapeutics and technologies.

RiboCraft Alpha

N1 Lab’s RiboCraft technology is evolved from the RNA delivery technology developed by N1 Life . It is designed and produced at the highest standards for efficacy, safety and stability.

90%-99%

mRNA transfection in immortalized cell lines

97%-99%

mRNA encapsulation efficiency

99%

>90% cell viability in most
tested cell lines

Versatile in Performance

In laboratory settings, RiboCraft Alpha demonstrates exceptional effectiveness in vitro, outperforming competitors in transfecting various cell cultures with mRNA, leading to remarkably high levels of gene expression and cellular uptake.

RiboCraft Alpha：No other product on the market achieves the same level of efficient and consistent mRNA delivery in animal models, marking RiboCraft Alpha as a groundbreaking leader in achieving enhanced gene expression with unmatched success.

RiboCraft Alpha is a robust tool to encapsulate, protect and deliver multi-component RNA mixtures. It has shown superior delivery capability of CRISPR/Cas gene editing system in cellular models when compared to marketed product.

Robust in Application

RiboCraft Alpha sets itself apart as a one-of-a-kind transfection reagent, uniquely suited for both in vitro and in vivo RNA transfection. This dual-function capability is a rare find in the market, offering unparalleled convenience and efficiency for researchers exploring the frontiers of genetic manipulation. RiboCraft Alpha offers research programs the unique ability to directly translate from cell-based assays to animal studies.